Is Breast Tumor Progression Really Linear?
نویسندگان
چکیده
منابع مشابه
Is breast tumor progression really linear?
In real life, most of us are likely to agree with this quote from Goethe. Yet, our generally accepted view of tumor progression depicts a linear route going from a normal cell to a metastatic tumor driven by progressively accumulating genetic, epigenetic, and microenvironmental alterations. Tumorigenesis has been described as an evolutionary process decades ago (1, 2), but still very few molecu...
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In the human genome, chromosome 11 contains a cluster of matrix metalloproteinase (MMP) genes. Single nucleotide polymorphisms in the promoter region of MMP genes are important for MMP expression. A common adenine deletion polymorphism (5A) at position -1171 of the MMP-3 gene promoter (5´-AAAAAACCAT-3´ change to 5´-AAAAACCAT-3´) facilitates transcriptional factor binding and MMP-3 promoter acti...
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PURPOSE The S100 gene family, which comprises over 20 members, including S100A1, S100A2, S100A8, S100A9, profilaggrin, and hornerin encodes low molecular weight calcium-binding proteins with physiological and pathological roles in keratinization. Recent studies have suggested a link between S100 proteins and human cancer progression. The purpose of the present study was to determine the express...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2008
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-07-2188